Decreased insulin secretion and accumulation of triglyceride in beta cells overexpressing a dominant-negative form of AMP-activated protein kinase.

Okazaki, Yukiko; Eto, Kazuhiro; Yamashita, Tokuyuki; Okamoto, Masayuki; Ohsugi, Mitsuru; Noda, Mitsuhiko; Terauchi, Yasuo; Ueki, Kohjiro; Kadowaki, Takashi

Okazaki, Yukiko; Eto, Kazuhiro; Yamashita, Tokuyuki; Okamoto, Masayuki; Ohsugi, Mitsuru; Noda, Mitsuhiko; Terauchi, Yasuo; Ueki, Kohjiro; Kadowaki, Takashi.

Affiliation

Okazaki Y; Department of Metabolic Diseases, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, Japan.

Endocr J ; 57(2): 141-52, 2010.

Article in En | MEDLINE | ID: mdl-19926919

Subject(s)

AMP-Activated Protein Kinases/genetics; Insulin-Secreting Cells/metabolism; Insulin/metabolism; Triglycerides/metabolism; AMP-Activated Protein Kinases/biosynthesis; Acetyl-CoA Carboxylase/metabolism; Glyburide/pharmacology; Humans; Insulin Secretion; Palmitates/metabolism; Potassium Chloride/pharmacology; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Triglycerides / Insulin-Secreting Cells / AMP-Activated Protein Kinases / Insulin Limits: Humans Language: En Journal: Endocr J Journal subject: ENDOCRINOLOGIA Year: 2010 Document type: Article Affiliation country: Japan Country of publication: Japan

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