Quantum dot-mediated photoproduction of reactive oxygen species for cancer cell annihilation.
Photochem Photobiol
; 86(2): 431-7, 2010.
Article
in En
| MEDLINE
| ID: mdl-19930115
ABSTRACT
While semiconductor quantum dots produce little singlet oxygen, they may undergo Type I photoreactions to produce other reactive oxygen species (ROS) to kill cells. CdTe quantum dots coated with thioglycolic acid were used to test that possibility. Some thiol ligands were purposely removed to regenerate the surface electron traps that were passivated by the ligand. This allowed photoinduced electrons to dwell on the surface long enough to be gathered by nearby oxygen molecules to produce ROS. The photocytotoxicity of these quantum dots was tested on nasopharyngeal carcinoma cells. Photokilling was shown to be drug and light dose dependent. Using 0.6 mum quantum dots for incubation and 4.8 J cm(-2) for irradiation, about 80% of the cells were annihilated. These quantum dots promised to be potent sensitizers for photoannihilation of cancer cells.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Reactive Oxygen Species
/
Quantum Dots
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Photochem Photobiol
Year:
2010
Document type:
Article
Affiliation country:
China