Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes alpha7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons.

Hruska, Martin; Keefe, Julie; Wert, David; Tekinay, Ayse Begum; Hulce, Jonathan J; Ibañez-Tallon, Ines; Nishi, Rae

Hruska, Martin; Keefe, Julie; Wert, David; Tekinay, Ayse Begum; Hulce, Jonathan J; Ibañez-Tallon, Ines; Nishi, Rae.

Affiliation

Hruska M; Department of Anatomy, University of Vermont College of Medicine, Burlington, Vermont 05405, USA.

J Neurosci ; 29(47): 14847-54, 2009 Nov 25.

Article in En | MEDLINE | ID: mdl-19940180

Subject(s)

Apoptosis/genetics; Avian Proteins/metabolism; Ganglia, Parasympathetic/metabolism; Neurons/metabolism; Neurotoxins/metabolism; Receptors, Nicotinic/metabolism; Adaptor Proteins, Signal Transducing; Amino Acid Sequence/genetics; Animals; Antigens, Neoplasm; Avian Proteins/genetics; Base Sequence/genetics; Chickens; GPI-Linked Proteins; Ganglia, Parasympathetic/embryology; Gene Expression Regulation, Developmental/genetics; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Mice; Molecular Sequence Data; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; Neurons/cytology; Neuropeptides/genetics; Neuropeptides/metabolism; Nicotinic Agonists/pharmacology; Nicotinic Antagonists/metabolism; Sequence Homology, Nucleic Acid; Telencephalon/embryology; Telencephalon/metabolism; alpha7 Nicotinic Acetylcholine Receptor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Nicotinic / Apoptosis / Avian Proteins / Ganglia, Parasympathetic / Neurons / Neurotoxins Limits: Animals Language: En Journal: J Neurosci Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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