1.45 A resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state.

Chojnowski, Grzegorz; Breer, Katarzyna; Narczyk, Marta; Wielgus-Kutrowska, Beata; Czapinska, Honorata; Hashimoto, Mariko; Hikishima, Sadao; Yokomatsu, Tsutomu; Bochtler, Matthias; Girstun, Agnieszka; Staron, Krzysztof; Bzowska, Agnieszka

Chojnowski, Grzegorz; Breer, Katarzyna; Narczyk, Marta; Wielgus-Kutrowska, Beata; Czapinska, Honorata; Hashimoto, Mariko; Hikishima, Sadao; Yokomatsu, Tsutomu; Bochtler, Matthias; Girstun, Agnieszka; Staron, Krzysztof; Bzowska, Agnieszka.

Affiliation

Chojnowski G; Department of Biophysics, Institute of Experimental Physics, University of Warsaw, Zwirki i Wigury 93, 02-089 Warsaw, Poland.

Biochem Biophys Res Commun ; 391(1): 703-8, 2010 Jan 01.

Article in En | MEDLINE | ID: mdl-19944078

Subject(s)

Enzyme Inhibitors/chemistry; Guanine/analogs & derivatives; Organophosphonates/chemistry; Purine-Nucleoside Phosphorylase/chemistry; Recombinant Proteins/chemistry; Animals; Binding Sites; Cattle; Crystallography, X-Ray; Enzyme Inhibitors/pharmacology; Glutamic Acid/chemistry; Glutamine/chemistry; Glycine/chemistry; Guanine/chemistry; Guanine/pharmacology; Organophosphonates/pharmacology; Phosphates/chemistry; Protein Multimerization; Purine-Nucleoside Phosphorylase/antagonists & inhibitors; Recombinant Proteins/antagonists & inhibitors; Ribose/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Proteins / Purine-Nucleoside Phosphorylase / Enzyme Inhibitors / Organophosphonates / Guanine Limits: Animals Language: En Journal: Biochem Biophys Res Commun Year: 2010 Document type: Article Affiliation country: Poland

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