Branchio-Oto-Renal Syndrome/genetics; Ear; Intracellular Signaling Peptides and Proteins; Mutation; Nuclear Proteins; Protein Tyrosine Phosphatases; Xenopus Proteins; Xenopus laevis; Amino Acid Sequence; Animals; Basic Helix-Loop-Helix Transcription Factors/genetics; Basic Helix-Loop-Helix Transcription Factors/metabolism; Branchio-Oto-Renal Syndrome/pathology; Branchio-Oto-Renal Syndrome/physiopathology; Disease Models, Animal; Ear/abnormalities; Ear/embryology; Embryo, Nonmammalian/abnormalities; Embryo, Nonmammalian/anatomy & histology; Embryo, Nonmammalian/metabolism; Eye Proteins/genetics; Eye Proteins/metabolism; Gene Expression Regulation, Developmental; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Humans; Intracellular Signaling Peptides and Proteins/genetics; Intracellular Signaling Peptides and Proteins/metabolism; Molecular Sequence Data; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Protein Tyrosine Phosphatases/genetics; Protein Tyrosine Phosphatases/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Sequence Alignment; Transcription Factors/genetics; Transcription Factors/metabolism; Xenopus Proteins/genetics; Xenopus Proteins/metabolism; Xenopus laevis/abnormalities; Xenopus laevis/anatomy & histology; Xenopus laevis/embryology