A 3-D model for 5-HT1A-receptor agonists based on stereoselective methyl-substituted and conformationally restricted analogues of 8-hydroxy-2-(dipropylamino)tetralin.

Mellin, C; Vallgårda, J; Nelson, D L; Björk, L; Yu, H; Andén, N E; Csöregh, I; Arvidsson, L E; Hacksell, U

Mellin, C; Vallgårda, J; Nelson, D L; Björk, L; Yu, H; Andén, N E; Csöregh, I; Arvidsson, L E; Hacksell, U.

Affiliation

Mellin C; Department of Organic Pharmaceutical Chemistry, Uppsala Biomedical Centre, Uppsala University, Sweden.

J Med Chem ; 34(2): 497-510, 1991 Feb.

Article in En | MEDLINE | ID: mdl-1995871

Subject(s)

Receptors, Serotonin/drug effects; Tetrahydronaphthalenes/chemical synthesis; Animals; Chemical Phenomena; Chemistry; Male; Models, Molecular; Rats; Rats, Inbred Strains; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes/pharmacology; X-Ray Diffraction

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Collection: 01-internacional Database: MEDLINE Main subject: Tetrahydronaphthalenes / Receptors, Serotonin Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1991 Document type: Article Affiliation country: Sweden Country of publication: United States

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