Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family.

Sohma, Youhei; Hua, Qing-xin; Liu, Ming; Phillips, Nelson B; Hu, Shi-Quan; Whittaker, Jonathan; Whittaker, Linda J; Ng, Aubree; Roberts, Charles T; Arvan, Peter; Kent, Stephen B H; Weiss, Michael A

Sohma, Youhei; Hua, Qing-xin; Liu, Ming; Phillips, Nelson B; Hu, Shi-Quan; Whittaker, Jonathan; Whittaker, Linda J; Ng, Aubree; Roberts, Charles T; Arvan, Peter; Kent, Stephen B H; Weiss, Michael A.

Affiliation

Sohma Y; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA.

J Biol Chem ; 285(7): 5040-55, 2010 Feb 12.

Article in En | MEDLINE | ID: mdl-19959476

Subject(s)

Insulin-Like Growth Factor I/chemistry; Insulin-Like Growth Factor I/pharmacology; Insulin/chemistry; Insulin/pharmacology; Animals; Cell Line; Circular Dichroism; Disulfides; Glycosylation; Humans; Insulin/chemical synthesis; Insulin-Like Growth Factor I/chemical synthesis; Magnetic Resonance Spectroscopy; Mice; Phosphorylation/drug effects; Proinsulin/biosynthesis; Proinsulin/genetics; Proinsulin/metabolism; Protein Folding; Protein Stability; Signal Transduction/drug effects; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin-Like Growth Factor I / Insulin Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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