A spleen tyrosine kinase inhibitor reduces the severity of established glomerulonephritis.

Smith, Jennifer; McDaid, John P; Bhangal, Gurjeet; Chawanasuntorapoj, Ratana; Masuda, Esteban S; Cook, H Terence; Pusey, Charles D; Tam, Frederick W K

Smith, Jennifer; McDaid, John P; Bhangal, Gurjeet; Chawanasuntorapoj, Ratana; Masuda, Esteban S; Cook, H Terence; Pusey, Charles D; Tam, Frederick W K.

Affiliation

Smith J; Imperial College Kidney and Transplant Institute, Division of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom.

J Am Soc Nephrol ; 21(2): 231-6, 2010 Feb.

Article in En | MEDLINE | ID: mdl-19959716

Subject(s)

Glomerulonephritis/metabolism; Glomerulonephritis/physiopathology; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors; Oxazines/pharmacology; Protein-Tyrosine Kinases/antagonists & inhibitors; Pyridines/pharmacology; Severity of Illness Index; Aminopyridines; Animals; Cells, Cultured; Chemokine CCL2/metabolism; Disease Models, Animal; Glomerulonephritis/pathology; Interleukin-1beta/metabolism; Intracellular Signaling Peptides and Proteins/metabolism; Macrophages/drug effects; Macrophages/metabolism; Macrophages/pathology; Mesangial Cells/drug effects; Mesangial Cells/metabolism; Mesangial Cells/pathology; Morpholines; Protein-Tyrosine Kinases/metabolism; Pyrimidines; Rats; Rats, Inbred WKY; Signal Transduction/physiology; Syk Kinase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxazines / Pyridines / Severity of Illness Index / Protein-Tyrosine Kinases / Intracellular Signaling Peptides and Proteins / Glomerulonephritis Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Am Soc Nephrol Journal subject: NEFROLOGIA Year: 2010 Document type: Article Affiliation country: United kingdom Country of publication: United States

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