Your browser doesn't support javascript.
loading
Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators.
Yang, Feng V; Shipe, William D; Bunda, Jaime L; Nolt, M Brad; Wisnoski, David D; Zhao, Zhijian; Barrow, James C; Ray, William J; Ma, Lei; Wittmann, Marion; Seager, Matthew A; Koeplinger, Kenneth A; Hartman, George D; Lindsley, Craig W.
Affiliation
  • Yang FV; Department of Medicinal Chemistry, Merck Research Laboratories, 770 Sumneytown Pike, PO Box 4, West Point, PA 19486, USA.
Bioorg Med Chem Lett ; 20(2): 531-6, 2010 Jan 15.
Article in En | MEDLINE | ID: mdl-20004574
ABSTRACT
An iterative analog library synthesis approach was employed in the exploration of a quinolone carboxylic acid series of selective M(1) positive allosteric modulators, and strategies for improving potency and plasma free fraction were identified.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Carboxylic Acids / Receptor, Muscarinic M1 Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States Publication country: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Carboxylic Acids / Receptor, Muscarinic M1 Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States Publication country: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM