A dual action of rheumatoid arthritis synovial fibroblast IL-15 expression on the equilibrium between CD4+CD25+ regulatory T cells and CD4+CD25- responder T cells.

Benito-Miguel, Marta; García-Carmona, Yolanda; Balsa, Alejandro; Pérez de Ayala, Carlos; Cobo-Ibáñez, Tatiana; Martín-Mola, Emilio; Miranda-Carús, María-Eugenia

Benito-Miguel, Marta; García-Carmona, Yolanda; Balsa, Alejandro; Pérez de Ayala, Carlos; Cobo-Ibáñez, Tatiana; Martín-Mola, Emilio; Miranda-Carús, María-Eugenia.

Affiliation

Benito-Miguel M; Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain.

J Immunol ; 183(12): 8268-79, 2009 Dec 15.

Article in En | MEDLINE | ID: mdl-20007590

Subject(s)

Arthritis, Rheumatoid/immunology; Arthritis, Rheumatoid/pathology; Fibroblasts/immunology; Fibroblasts/pathology; Interleukin-15/biosynthesis; Synovial Membrane/immunology; Synovial Membrane/pathology; T-Lymphocytes, Regulatory/immunology; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid/metabolism; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/metabolism; CD4-Positive T-Lymphocytes/pathology; Cells, Cultured; Coculture Techniques; Down-Regulation/immunology; Female; Fibroblasts/metabolism; Gene Expression Regulation/immunology; Humans; Inflammation Mediators/metabolism; Inflammation Mediators/physiology; Interleukin-15/genetics; Interleukin-15/physiology; Lymphocyte Activation/immunology; Male; Middle Aged; Osteoarthritis/immunology; Osteoarthritis/metabolism; Osteoarthritis/pathology; Synovial Membrane/metabolism; T-Lymphocytes, Regulatory/metabolism; T-Lymphocytes, Regulatory/pathology; Up-Regulation/immunology; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Synovial Membrane / T-Lymphocytes, Regulatory / Interleukin-15 / Fibroblasts Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: J Immunol Year: 2009 Document type: Article Affiliation country: Spain

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