Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.
Antimicrob Agents Chemother
; 54(2): 673-7, 2010 Feb.
Article
in En
| MEDLINE
| ID: mdl-20008781
ABSTRACT
We tested the propensity of three quinolones to select for resistant Streptococcus pneumoniae mutants by determining the mutant prevention concentration (MPC) against 100 clinical strains, some of which harbored mutations in type II topoisomerases. Compared with levofloxacin and gemifloxacin, moxifloxacin had the lowest number of strains with MPCs above the susceptibility breakpoint (P<0.001), thus representing a lower selective pressure for proliferation of resistant mutants. Only moxifloxacin gave a 50% MPC (MPC50) value (1 microg/ml) within the susceptible range.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quinolines
/
Streptococcus pneumoniae
/
Aza Compounds
/
Ofloxacin
/
Fluoroquinolones
/
Levofloxacin
/
Anti-Bacterial Agents
/
Naphthyridines
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
2010
Document type:
Article
Affiliation country:
United States