The CRF system, stress, depression and anxiety-insights from human genetic studies.
Mol Psychiatry
; 15(6): 574-88, 2010 Jun.
Article
in En
| MEDLINE
| ID: mdl-20010888
ABSTRACT
A concatenation of findings from preclinical and clinical studies support a preeminent function for the corticotropin-releasing factor (CRF) system in mediating the physiological response to external stressors and in the pathophysiology of anxiety and depression. Recently, human genetic studies have provided considerable support to several long-standing hypotheses of mood and anxiety disorders, including the CRF hypothesis. These data, reviewed in this report, are congruent with the hypothesis that this system is of paramount importance in mediating stress-related psychopathology. More specifically, variants in the gene encoding the CRF(1) receptor interact with adverse environmental factors to predict risk for stress-related psychiatric disorders. In-depth characterization of these variants will likely be important in furthering our understanding of the long-term consequences of adverse experience.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anxiety Disorders
/
Stress, Psychological
/
Corticotropin-Releasing Hormone
/
Receptors, Corticotropin-Releasing Hormone
/
Depression
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Mol Psychiatry
Journal subject:
BIOLOGIA MOLECULAR
/
PSIQUIATRIA
Year:
2010
Document type:
Article
Affiliation country:
Germany