Amides/therapeutic use; Antihypertensive Agents/therapeutic use; Cardiovascular Diseases/prevention & control; Diabetic Nephropathies/drug therapy; Fumarates/therapeutic use; Heart Failure/drug therapy; Hypertension/drug therapy; Renin-Angiotensin System; Renin/antagonists & inhibitors; Amides/administration & dosage; Angiotensin II/physiology; Angiotensin II Type 1 Receptor Blockers/administration & dosage; Angiotensin II Type 1 Receptor Blockers/therapeutic use; Antihypertensive Agents/administration & dosage; Biphenyl Compounds/administration & dosage; Biphenyl Compounds/therapeutic use; Cardiovascular Diseases/mortality; Diuretics/administration & dosage; Diuretics/therapeutic use; Drug Therapy, Combination; Europe/epidemiology; Fumarates/administration & dosage; Germany/epidemiology; Heart Failure/mortality; Humans; Hydrochlorothiazide/administration & dosage; Hydrochlorothiazide/therapeutic use; Hypertension/blood; Hypertension/epidemiology; Irbesartan; Japan/epidemiology; Prevalence; Protein Precursors/physiology; Randomized Controlled Trials as Topic; Receptors, Cell Surface/physiology; Renin/blood; Renin/physiology; Renin-Angiotensin System/drug effects; Renin-Angiotensin System/physiology; Risk Factors; Tetrazoles/administration & dosage; Tetrazoles/therapeutic use; Time Factors; World Health Organization; Prorenin Receptor