Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells.

Zhang, Linxia; Seitz, Linsey C; Abramczyk, Amy M; Chan, Christina

Zhang, Linxia; Seitz, Linsey C; Abramczyk, Amy M; Chan, Christina.

Affiliation

Zhang L; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, USA.

Exp Cell Res ; 316(5): 716-27, 2010 Mar 10.

Article in En | MEDLINE | ID: mdl-20026039

Subject(s)

Cell Death/drug effects; Cyclic AMP/metabolism; Hep G2 Cells; Mitochondria/drug effects; Mitochondria/metabolism; Palmitates; 1-Methyl-3-isobutylxanthine/metabolism; Animals; Apoptosis Regulatory Proteins; Caspases/metabolism; Cell Death/physiology; Colforsin/metabolism; Dose-Response Relationship, Drug; Fatty Acids/metabolism; Hep G2 Cells/drug effects; Hep G2 Cells/physiology; Humans; Intracellular Signaling Peptides and Proteins/metabolism; Mitochondria/ultrastructure; Mitochondrial Proteins/metabolism; Oxidation-Reduction; Palmitates/metabolism; Palmitates/pharmacology; Phosphodiesterase Inhibitors/metabolism; Reactive Oxygen Species/antagonists & inhibitors; Reactive Oxygen Species/metabolism; Triglycerides/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Palmitates / Cell Death / Cyclic AMP / Hep G2 Cells / Mitochondria Limits: Animals / Humans Language: En Journal: Exp Cell Res Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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