Oxime carbamate--discovery of a series of novel FAAH inhibitors.

Sit, S Y; Conway, Charles M; Xie, Kai; Bertekap, Robert; Bourin, Clotilde; Burris, Kevin D

Sit, S Y; Conway, Charles M; Xie, Kai; Bertekap, Robert; Bourin, Clotilde; Burris, Kevin D.

Affiliation

Sit SY; Department of Chemistry, Bristol-Myers Squibb Research & Development, 5 Research Parkway, Wallingford, CT 06492-7660, USA. sits@bms.com

Bioorg Med Chem Lett ; 20(3): 1272-7, 2010 Feb 01.

Article in En | MEDLINE | ID: mdl-20036536

Subject(s)

Amidohydrolases/antagonists & inhibitors; Carbamates/chemistry; Drug Discovery/methods; Oximes/chemistry; Oximes/pharmacology; Amidohydrolases/physiology; Animals; Cannabinoid Receptor Modulators/physiology; Carbamates/metabolism; Carbamates/pharmacology; Cell Line; Crystallography, X-Ray; Humans; Oximes/metabolism; Protein Binding/physiology; Protein Structure, Tertiary; Rats; Signal Transduction/drug effects; Signal Transduction/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oximes / Carbamates / Drug Discovery / Amidohydrolases Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United kingdom

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