2-Dialkynyl derivatives of (N)-methanocarba nucleosides: 'Clickable' A(3) adenosine receptor-selective agonists.

Tosh, Dilip K; Chinn, Moshe; Yoo, Lena S; Kang, Dong Wook; Luecke, Hans; Gao, Zhan-Guo; Jacobson, Kenneth A

Tosh, Dilip K; Chinn, Moshe; Yoo, Lena S; Kang, Dong Wook; Luecke, Hans; Gao, Zhan-Guo; Jacobson, Kenneth A.

Affiliation

Tosh DK; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8A, Rm. B1A-19, NIH, NIDDK, LBC, Bethesda, MD 20892, United States.

Bioorg Med Chem ; 18(2): 508-17, 2010 Jan 15.

Article in En | MEDLINE | ID: mdl-20036562

Subject(s)

Adenosine A3 Receptor Agonists; Alkynes/pharmacology; Nucleosides/pharmacology; Alkynes/chemical synthesis; Alkynes/chemistry; Animals; CHO Cells; Cells, Cultured; Cricetinae; Cricetulus; Drug Design; Humans; Molecular Structure; Nucleosides/chemical synthesis; Nucleosides/chemistry; Receptor, Adenosine A3/metabolism; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alkynes / Adenosine A3 Receptor Agonists / Nucleosides Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United kingdom

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