Enzyme-assisted synthesis and structural characterization of pure benzodiazepine glucuronide epimers.

Pallmann, T; Jonas, U; Wagner, M; Thevis, M; Kaeferstein, H; Rothschild, M A; Bender, K

Pallmann, T; Jonas, U; Wagner, M; Thevis, M; Kaeferstein, H; Rothschild, M A; Bender, K.

Affiliation

Pallmann T; Institute of Legal Medicine, University Hospital of Cologne, Melatengürtel 60-62, D-50823 Cologne, Germany.

Eur J Pharm Sci ; 39(4): 233-40, 2010 Feb 19.

Article in En | MEDLINE | ID: mdl-20036738

Subject(s)

Benzodiazepines/chemical synthesis; Glucuronides/chemical synthesis; Animals; Benzodiazepines/chemistry; Benzodiazepines/metabolism; Chromatography, High Pressure Liquid; Glucuronides/chemistry; Glucuronides/metabolism; Glucuronosyltransferase/chemical synthesis; Glucuronosyltransferase/chemistry; Glucuronosyltransferase/metabolism; Magnetic Resonance Spectroscopy; Microsomes, Liver/drug effects; Microsomes, Liver/enzymology; Rats; Stereoisomerism; Swine; Uridine Diphosphate Glucuronic Acid/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzodiazepines / Glucuronides Limits: Animals Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2010 Document type: Article Affiliation country: Germany Country of publication: Netherlands

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