Optimization of a pipemidic acid autotaxin inhibitor.

Hoeglund, Adrienne B; Bostic, Heidi E; Howard, Angela L; Wanjala, Irene W; Best, Michael D; Baker, Daniel L; Parrill, Abby L

Hoeglund, Adrienne B; Bostic, Heidi E; Howard, Angela L; Wanjala, Irene W; Best, Michael D; Baker, Daniel L; Parrill, Abby L.

Affiliation

Hoeglund AB; Department of Chemistry, The University of Memphis, Memphis, Tennessee 38152, USA.

J Med Chem ; 53(3): 1056-66, 2010 Feb 11.

Article in En | MEDLINE | ID: mdl-20041668

Subject(s)

Enzyme Inhibitors/pharmacology; Lysophospholipids/metabolism; Multienzyme Complexes/chemistry; Multienzyme Complexes/metabolism; Phosphodiesterase I/chemistry; Phosphodiesterase I/metabolism; Pipemidic Acid/chemistry; Pyrophosphatases/chemistry; Pyrophosphatases/metabolism; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Computer-Aided Design; Drug Evaluation, Preclinical; Enzyme Assays; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/chemistry; Female; Humans; Lysophosphatidylcholines/metabolism; Phosphoric Diester Hydrolases/chemistry; Phosphoric Diester Hydrolases/metabolism; Quantitative Structure-Activity Relationship; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pipemidic Acid / Pyrophosphatases / Lysophospholipids / Phosphodiesterase I / Enzyme Inhibitors / Multienzyme Complexes Limits: Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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