Upregulation of elastase activity in aorta in mucopolysaccharidosis I and VII dogs may be due to increased cytokine expression.

Metcalf, Jason A; Linders, Bruce; Wu, Susan; Bigg, Paul; O'Donnell, Patricia; Sleeper, Meg M; Whyte, Michael P; Haskins, Mark; Ponder, Katherine P

Metcalf, Jason A; Linders, Bruce; Wu, Susan; Bigg, Paul; O'Donnell, Patricia; Sleeper, Meg M; Whyte, Michael P; Haskins, Mark; Ponder, Katherine P.

Affiliation

Metcalf JA; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Mol Genet Metab ; 99(4): 396-407, 2010 Apr.

Article in En | MEDLINE | ID: mdl-20044292

Subject(s)

Aorta/enzymology; Dog Diseases/enzymology; Mucopolysaccharidosis I/enzymology; Mucopolysaccharidosis I/veterinary; Mucopolysaccharidosis VII/enzymology; Pancreatic Elastase/metabolism; Up-Regulation; Animals; Aortic Diseases/complications; Cathepsins/metabolism; Dogs; Elastin/metabolism; Humans; Male; Matrix Metalloproteinase 12/metabolism; Mucopolysaccharidosis VII/veterinary; Young Adult

Key words

Mucopolysaccharidosis; aorta; canine; cathepsin S; elastin; gene therapy; lysosomal storage disease

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aorta / Pancreatic Elastase / Up-Regulation / Mucopolysaccharidosis VII / Mucopolysaccharidosis I / Dog Diseases Type of study: Prognostic_studies Limits: Adult / Animals / Humans / Male Language: En Journal: Mol Genet Metab Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / METABOLISMO Year: 2010 Document type: Article Affiliation country: United States

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