Cardiomyopathy, Hypertrophic/metabolism; Heart Failure/metabolism; Muscle Proteins/metabolism; Myocardial Contraction; Myocytes, Cardiac/metabolism; Ventricular Function, Left; Age Factors; Aging; Animals; Cardiomyopathy, Hypertrophic/complications; Cardiomyopathy, Hypertrophic/genetics; Cardiomyopathy, Hypertrophic/physiopathology; Cells, Cultured; Connectin; Disease Models, Animal; Fibrosis; Gene Knock-In Techniques; Genotype; Heart Failure/genetics; Heart Failure/physiopathology; Heterozygote; Homozygote; LIM Domain Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle Proteins/genetics; Muscle, Skeletal/metabolism; Muscle, Skeletal/pathology; Mutation, Missense; Myocytes, Cardiac/pathology; Phenotype; Polymorphism, Single Nucleotide; RNA, Messenger/metabolism; Rats; Recombinant Fusion Proteins/metabolism; Transfection