Tamoxifen alleviates irradiation-induced brain injury by attenuating microglial inflammatory response in vitro and in vivo.

Liu, Jun-Li; Tian, Dai-Shi; Li, Zai-Wang; Qu, Wen-Sheng; Zhan, Yan; Xie, Min-Jie; Yu, Zhi-Yuan; Wang, Wei; Wu, Gang

Liu, Jun-Li; Tian, Dai-Shi; Li, Zai-Wang; Qu, Wen-Sheng; Zhan, Yan; Xie, Min-Jie; Yu, Zhi-Yuan; Wang, Wei; Wu, Gang.

Affiliation

Liu JL; Cancer center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, PR China.

Brain Res ; 1316: 101-11, 2010 Feb 26.

Article in En | MEDLINE | ID: mdl-20044983

Subject(s)

Anti-Inflammatory Agents/pharmacology; Brain Injuries/drug therapy; Microglia/drug effects; Neuroprotective Agents/pharmacology; Radiation Injuries, Experimental/drug therapy; Tamoxifen/pharmacology; Animals; Astrocytes/physiology; Astrocytes/radiation effects; Brain/drug effects; Brain/immunology; Brain/radiation effects; Brain Injuries/immunology; Cell Line; Culture Media, Conditioned; Cytokines/metabolism; Interleukin-1beta/metabolism; Male; Mice; Microglia/immunology; Microglia/radiation effects; Neurons/physiology; Neurons/radiation effects; Radiation Injuries, Experimental/immunology; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiation Injuries, Experimental / Tamoxifen / Brain Injuries / Microglia / Neuroprotective Agents / Anti-Inflammatory Agents Type of study: Prognostic_studies Aspects: Patient_preference Limits: Animals Language: En Journal: Brain Res Year: 2010 Document type: Article Country of publication: Netherlands

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