Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia.

Sasu, Barbra J; Cooke, Keegan S; Arvedson, Tara L; Plewa, Cherylene; Ellison, Aaron R; Sheng, Jackie; Winters, Aaron; Juan, Todd; Li, Hongyan; Begley, C Glenn; Molineux, Graham

Sasu, Barbra J; Cooke, Keegan S; Arvedson, Tara L; Plewa, Cherylene; Ellison, Aaron R; Sheng, Jackie; Winters, Aaron; Juan, Todd; Li, Hongyan; Begley, C Glenn; Molineux, Graham.

Affiliation

Sasu BJ; Department of Hematology/Oncology, Amgen Inc, Thousand Oaks, CA 91320, USA. bajohnso@amgen.com

Blood ; 115(17): 3616-24, 2010 Apr 29.

Article in En | MEDLINE | ID: mdl-20053755

Subject(s)

Anemia, Iron-Deficiency/drug therapy; Antibodies, Neutralizing/pharmacology; Antimicrobial Cationic Peptides/antagonists & inhibitors; Iron/metabolism; Anemia, Iron-Deficiency/genetics; Anemia, Iron-Deficiency/immunology; Anemia, Iron-Deficiency/metabolism; Animals; Antibodies, Neutralizing/immunology; Antimicrobial Cationic Peptides/biosynthesis; Antimicrobial Cationic Peptides/genetics; Antimicrobial Cationic Peptides/immunology; Brucella abortus; Disease Models, Animal; Erythropoiesis/drug effects; Erythropoiesis/genetics; Hepcidins; Humans; Inflammation/complications; Inflammation/drug therapy; Inflammation/genetics; Inflammation/immunology; Inflammation/metabolism; Mice; Mice, Transgenic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anemia, Iron-Deficiency / Antimicrobial Cationic Peptides / Antibodies, Neutralizing / Iron Limits: Animals / Humans Language: En Journal: Blood Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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