Identification of an anticoagulant peptide that inhibits both fXIa and fVIIa/tissue factor from the blood-feeding nematode Ancylostoma caninum.

Li, Deng; He, Qingfeng; Kang, Tao; Yin, Huan; Jin, Xian; Li, Hui; Gan, Weiqiong; Yang, Chen; Hu, Jingjing; Wu, Yamin; Peng, Lifei

Li, Deng; He, Qingfeng; Kang, Tao; Yin, Huan; Jin, Xian; Li, Hui; Gan, Weiqiong; Yang, Chen; Hu, Jingjing; Wu, Yamin; Peng, Lifei.

Affiliation

Li D; Department of Parasitology, Guangdong Medical College, Zhanjiang 524023, China.

Biochem Biophys Res Commun ; 392(2): 155-9, 2010 Feb 05.

Article in En | MEDLINE | ID: mdl-20059979

Subject(s)

Ancylostoma/metabolism; Anticoagulants/pharmacology; Factor VII/antagonists & inhibitors; Factor XIa/antagonists & inhibitors; Peptides/pharmacology; Amino Acid Sequence; Ancylostoma/genetics; Animals; Anticoagulants/isolation & purification; Cloning, Molecular; DNA, Complementary/genetics; Humans; Molecular Sequence Data; Partial Thromboplastin Time; Peptides/genetics; Peptides/isolation & purification; Prothrombin Time

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Factor VII / Factor XIa / Ancylostoma / Anticoagulants Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochem Biophys Res Commun Year: 2010 Document type: Article Affiliation country: China Country of publication: United States

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