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Riboswitch RNAs: regulation of gene expression by direct monitoring of a physiological signal.
Smith, Angela M; Fuchs, Ryan T; Grundy, Frank J; Henkin, Tina M.
Affiliation
  • Smith AM; Department of Microbiology and Center for RNA Biology, Ohio State University, Columbus, OH, USA.
RNA Biol ; 7(1): 104-10, 2010.
Article in En | MEDLINE | ID: mdl-20061810
ABSTRACT
Riboswitches are cis-encoded, cis-acting RNA elements that directly sense a physiological signal. Signal response results in a change in RNA structure that impacts gene expression. Elements of this type play an important role in bacteria, where they regulate a variety of fundamental cellular pathways. Riboswitch-mediated gene regulation most commonly occurs by effects on transcription attenuation, to control whether a full-length transcript is synthesized, or on translation initiation, in which case the transcript is constitutively synthesized but binding of the translation initiation complex is modulated. An overview of the role of riboswitch RNAs in bacterial gene expression will be provided, and a few examples are described in more detail to illustrate the types of mechanisms that have been uncovered.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteria / RNA, Bacterial / Signal Transduction / Gene Expression Regulation, Bacterial / Regulatory Sequences, Ribonucleic Acid Language: En Journal: RNA Biol Journal subject: BIOLOGIA MOLECULAR Year: 2010 Document type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteria / RNA, Bacterial / Signal Transduction / Gene Expression Regulation, Bacterial / Regulatory Sequences, Ribonucleic Acid Language: En Journal: RNA Biol Journal subject: BIOLOGIA MOLECULAR Year: 2010 Document type: Article Affiliation country: United States