Remote functionalization of SCH 39166: discovery of potent and selective benzazepine dopamine D1 receptor antagonists.

Sasikumar, T K; Burnett, Duane A; Greenlee, William J; Smith, Michelle; Fawzi, Ahmad; Zhang, Hongtao; Lachowicz, Jean E

Sasikumar, T K; Burnett, Duane A; Greenlee, William J; Smith, Michelle; Fawzi, Ahmad; Zhang, Hongtao; Lachowicz, Jean E.

Affiliation

Sasikumar TK; Department of Medicinal Chemistry and Metabolic Disorders, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. sasikumartk@yahoo.com

Bioorg Med Chem Lett ; 20(3): 832-5, 2010 Feb 01.

Article in En | MEDLINE | ID: mdl-20064718

Subject(s)

Benzazepines/chemistry; Dopamine Antagonists/chemistry; Receptors, Dopamine D1/antagonists & inhibitors; Animals; Benzazepines/pharmacology; Dopamine Antagonists/pharmacology; Male; Protein Binding/drug effects; Protein Binding/physiology; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzazepines / Receptors, Dopamine D1 / Dopamine Antagonists Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United kingdom

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