Copper-promoted coupling of vinyl boronates and alcohols: a mild synthesis of allyl vinyl ethers.
J Am Chem Soc
; 132(4): 1202-3, 2010 Feb 03.
Article
in En
| MEDLINE
| ID: mdl-20067245
ABSTRACT
A copper-promoted coupling of vinyl pinacol boronate esters and alcohols for the synthesis of enol ethers is reported. The reaction occurs in 50-99% yield and is compatible with a variety of functional groups. Cupric acetate is the copper source, and triethylamine buffer is used to prevent protodeboration; the reaction occurs at room temperature. In addition to excellent chemoselectivity, the reaction is stereospecific.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Am Chem Soc
Year:
2010
Document type:
Article
Affiliation country:
United States