Design and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/ref-1).

Nyland, Rodney L; Luo, Meihua; Kelley, Mark R; Borch, Richard F

Nyland, Rodney L; Luo, Meihua; Kelley, Mark R; Borch, Richard F.

Affiliation

Nyland RL; Department of Medicinal Chemistry and Molecular Pharmacology, Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA.

J Med Chem ; 53(3): 1200-10, 2010 Feb 11.

Article in En | MEDLINE | ID: mdl-20067291

Subject(s)

Benzoquinones/chemical synthesis; Benzoquinones/pharmacology; DNA-(Apurinic or Apyrimidinic Site) Lyase/antagonists & inhibitors; Drug Design; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Methacrylates/chemical synthesis; Methacrylates/pharmacology; Naphthoquinones/chemical synthesis; Naphthoquinones/pharmacology; Propionates/chemistry; Benzoquinones/chemistry; Cell Line, Tumor; Cell Proliferation/drug effects; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors/chemistry; Female; Humans; Magnetic Resonance Spectroscopy; Methacrylates/chemistry; Naphthoquinones/chemistry; Ovarian Neoplasms/drug therapy; Ovarian Neoplasms/pathology; Oxidation-Reduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Propionates / Drug Design / Benzoquinones / Naphthoquinones / DNA-(Apurinic or Apyrimidinic Site) Lyase / Enzyme Inhibitors / Methacrylates Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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