Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone.

Pochynyuk, Oleh; Rieg, Timo; Bugaj, Vladislav; Schroth, Jana; Fridman, Alla; Boss, Gerry R; Insel, Paul A; Stockand, James D; Vallon, Volker

Pochynyuk, Oleh; Rieg, Timo; Bugaj, Vladislav; Schroth, Jana; Fridman, Alla; Boss, Gerry R; Insel, Paul A; Stockand, James D; Vallon, Volker.

Affiliation

Pochynyuk O; Department of Physiology, University of Texas Health Science Center, San Antonio, Texas, USA.

FASEB J ; 24(6): 2056-65, 2010 Jun.

Article in En | MEDLINE | ID: mdl-20097874

Subject(s)

Epithelial Sodium Channels/metabolism; Kidney/metabolism; Receptors, Purinergic P2/physiology; Sodium, Dietary/administration & dosage; Sodium, Dietary/pharmacology; Adenosine Triphosphate/urine; Aldosterone/pharmacology; Animals; Blood Pressure/drug effects; Cells, Cultured; Electrophysiology; Homeostasis/drug effects; Kidney/cytology; Kidney/drug effects; Mice; Mice, Inbred C57BL; Mice, Knockout; Mineralocorticoids/pharmacology; Nephrons/cytology; Nephrons/drug effects; Nephrons/metabolism; Patch-Clamp Techniques; Receptors, Purinergic P2Y2; Signal Transduction; Uridine Triphosphate/urine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sodium, Dietary / Receptors, Purinergic P2 / Epithelial Sodium Channels / Kidney Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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