Releasable GABA in tubular epithelium of rat kidney.
Experientia
; 47(3): 227-9, 1991 Mar 15.
Article
in En
| MEDLINE
| ID: mdl-2009928
ABSTRACT
The distribution of gamma-aminobutyric acid (GABA) in the rat kidney was examined by immunocytochemical techniques. GABA-like immunoreactivity (GABA-LI) was predominantly confined to the renal tubules, including the ascending parts of the distal tubules, and the loops of Henle, the collecting tubules and ducts, and the connective parts of the convoluted tubules. In GABA-positive cortical tubules, about half of the epithelial cells were labelled. The labelled cell type showed the ultrastructural features of principal cells. Depolarizing stimulation by ouabain and high K+ concentration evoked the efflux of endogenous GABA from kidney slices. The present findings, along with previous results, suggest that GABA released from renal tubular epithelium, and transported with the urine, might be involved in the modulation of contractility in the urinary tract.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gamma-Aminobutyric Acid
/
Kidney Tubules
Limits:
Animals
Language:
En
Journal:
Experientia
Year:
1991
Document type:
Article