Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes.

Chu, Matthew L H; Lang, Zhaolei; Chavas, Leonard M G; Neres, João; Fedorova, Olga S; Tabernero, Lydia; Cherry, Mike; Williams, David H; Douglas, Kenneth T; Eyers, Patrick A

Chu, Matthew L H; Lang, Zhaolei; Chavas, Leonard M G; Neres, João; Fedorova, Olga S; Tabernero, Lydia; Cherry, Mike; Williams, David H; Douglas, Kenneth T; Eyers, Patrick A.

Affiliation

Chu ML; Wolfson Centre for Structure-Based Rational Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, UK.

Biochemistry ; 49(8): 1689-701, 2010 Mar 02.

Article in En | MEDLINE | ID: mdl-20099905

Subject(s)

Anthracenes/chemistry; Anthracenes/metabolism; Cell Cycle Proteins/antagonists & inhibitors; Cell Cycle Proteins/chemistry; Crystallography, X-Ray/methods; Protein Serine-Threonine Kinases/antagonists & inhibitors; Protein Serine-Threonine Kinases/chemistry; Catalytic Domain; Cell Cycle Proteins/metabolism; Humans; Molecular Structure; Protein Binding; Protein Serine-Threonine Kinases/metabolism; Protein Structure, Secondary; Protein-Tyrosine Kinases; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Serine-Threonine Kinases / Crystallography, X-Ray / Cell Cycle Proteins / Anthracenes Limits: Humans Language: En Journal: Biochemistry Year: 2010 Document type: Article Affiliation country: United kingdom Country of publication: United States

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