NFAT3 transcription factor inhibits breast cancer cell motility by targeting the Lipocalin 2 gene.
Oncogene
; 29(15): 2292-301, 2010 Apr 15.
Article
in En
| MEDLINE
| ID: mdl-20101218
ABSTRACT
NFAT1 and NFAT5 act as pro-invasive and pro-migratory transcription factors in breast carcinoma, contributing to the formation of metastases. We report that NFAT3 is specifically expressed in estrogen receptor alpha positive (ERA+) breast cancer cells. We show that NFAT3 inhibits by itself the invasion capacity of ERA+ breast cancer cells and needs to cooperate with ERA to inhibit their migration. Conversely, NFAT3 downregulation results in actin reorganization associated with increased migration and invasion capabilities. NFAT3 signaling reduces migration through inhibition of Lipocalin 2 (LCN2) gene expression. Collectively, our study unravels an earlier unknown NFAT3/LCN2 axis that critically controls motility in breast cancer.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Acute-Phase Proteins
/
Cell Movement
/
Proto-Oncogene Proteins
/
NFATC Transcription Factors
/
Lipocalins
Limits:
Humans
Language:
En
Journal:
Oncogene
Journal subject:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Year:
2010
Document type:
Article
Affiliation country:
France