Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors.

Wang, Shouming; Beck, Richard; Burd, Andrew; Blench, Toby; Marlin, Frederic; Ayele, Tenagne; Buxton, Stuart; Dagostin, Claudio; Malic, Maja; Joshi, Rina; Barry, John; Sajad, Mohammed; Cheung, Chiming; Shaikh, Shaheda; Chahwala, Suresh; Chander, Chaman; Baumgartner, Christine; Holthoff, Hans-Peter; Murray, Elizabeth; Blackney, Michael; Giddings, Amanda

Wang, Shouming; Beck, Richard; Burd, Andrew; Blench, Toby; Marlin, Frederic; Ayele, Tenagne; Buxton, Stuart; Dagostin, Claudio; Malic, Maja; Joshi, Rina; Barry, John; Sajad, Mohammed; Cheung, Chiming; Shaikh, Shaheda; Chahwala, Suresh; Chander, Chaman; Baumgartner, Christine; Holthoff, Hans-Peter; Murray, Elizabeth; Blackney, Michael; Giddings, Amanda.

Affiliation

Wang S; Department of Medicinal Chemistry, Trigen Ltd., Emmanuel Kaye Building, 1B Manresa Road,London SW3 6LR, UK. shouming_wang@yahoo.co.uk

J Med Chem ; 53(4): 1473-82, 2010 Feb 25.

Article in En | MEDLINE | ID: mdl-20121197

Subject(s)

Factor IXa/antagonists & inhibitors; Thiophenes/chemical synthesis; Animals; Carbamates/chemical synthesis; Carbamates/chemistry; Carbamates/pharmacokinetics; Crystallography, X-Ray; Drug Design; Factor IXa/chemistry; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Thiophenes/chemistry; Thiophenes/pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiophenes / Factor IXa Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Document type: Article Affiliation country: United kingdom Country of publication: United States

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