Stereospecific Suzuki cross-coupling of alkyl alpha-cyanohydrin triflates.
J Am Chem Soc
; 132(8): 2524-5, 2010 Mar 03.
Article
in En
| MEDLINE
| ID: mdl-20121273
ABSTRACT
Scalemic alpha-cyanohydrin triflates undergo Pd-catalyzed cross-coupling with aryl, heteroaryl, and vinyl boronic acids under mild conditions. Coupling proceeds with complete inversion of configuration at the stereogenic carbon. The resultant nitrile can be easily converted into a variety of alternative functional groups of value in organic synthesis and thus achieves a higher level of molecular complexity than the products of traditional Suzuki reactions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nitriles
Language:
En
Journal:
J Am Chem Soc
Year:
2010
Document type:
Article
Affiliation country:
United States