2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics.

Zeng, Qingping; Bourbeau, Matthew P; Wohlhieter, G Erich; Yao, Guomin; Monenschein, Holger; Rider, James T; Lee, Matthew R; Zhang, Shiwen; Lofgren, Julie; Freeman, Daniel; Li, Chun; Tominey, Elizabeth; Huang, Xin; Hoffman, Douglas; Yamane, Harvey; Tasker, Andrew S; Dominguez, Celia; Viswanadhan, Vellarkad N; Hungate, Randall; Zhang, Xiaoling

Zeng, Qingping; Bourbeau, Matthew P; Wohlhieter, G Erich; Yao, Guomin; Monenschein, Holger; Rider, James T; Lee, Matthew R; Zhang, Shiwen; Lofgren, Julie; Freeman, Daniel; Li, Chun; Tominey, Elizabeth; Huang, Xin; Hoffman, Douglas; Yamane, Harvey; Tasker, Andrew S; Dominguez, Celia; Viswanadhan, Vellarkad N; Hungate, Randall; Zhang, Xiaoling.

Affiliation

Zeng Q; Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.

Bioorg Med Chem Lett ; 20(5): 1652-6, 2010 Mar 01.

Article in En | MEDLINE | ID: mdl-20137932

Subject(s)

Antineoplastic Agents/chemistry; Isoquinolines/chemistry; Protein Kinase Inhibitors/chemistry; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Thiadiazoles/chemistry; Thiazoles/chemistry; Animals; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacokinetics; Catalytic Domain; Crystallography, X-Ray; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases/metabolism; Cyclin-Dependent Kinase 2/antagonists & inhibitors; Cyclin-Dependent Kinase 2/metabolism; Isoquinolines/chemical synthesis; Isoquinolines/pharmacokinetics; Mice; Neoplasms/drug therapy; Phosphorylation; Protein Kinase Inhibitors/chemical synthesis; Protein Kinase Inhibitors/pharmacokinetics; Proto-Oncogene Proteins c-akt/metabolism; Rats; Structure-Activity Relationship; Thiadiazoles/chemical synthesis; Thiadiazoles/pharmacokinetics; Thiazoles/chemical synthesis; Thiazoles/pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiadiazoles / Thiazoles / Protein Kinase Inhibitors / Proto-Oncogene Proteins c-akt / Isoquinolines / Antineoplastic Agents Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United kingdom

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