Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

O'Neill, Heidi C; White, Carl W; Veress, Livia A; Hendry-Hofer, Tara B; Loader, Joan E; Min, Elysia; Huang, Jie; Rancourt, Raymond C; Day, Brian J

O'Neill, Heidi C; White, Carl W; Veress, Livia A; Hendry-Hofer, Tara B; Loader, Joan E; Min, Elysia; Huang, Jie; Rancourt, Raymond C; Day, Brian J.

Affiliation

O'Neill HC; Department of Pharmaceutical Sciences, University of Colorado at Denver Health Sciences Center, Denver, CO 80217, USA.

Free Radic Biol Med ; 48(9): 1188-96, 2010 May 01.

Article in En | MEDLINE | ID: mdl-20138141

Subject(s)

Antioxidants/pharmacology; Chemical Warfare Agents/toxicity; Metalloporphyrins/pharmacology; Mustard Gas/analogs & derivatives; Animals; Bronchoalveolar Lavage Fluid/chemistry; Bronchoalveolar Lavage Fluid/immunology; Inflammation/drug therapy; Inhalation Exposure; L-Lactate Dehydrogenase/drug effects; Lung/drug effects; Lung/immunology; Male; Mustard Gas/administration & dosage; Mustard Gas/toxicity; Oxidative Stress/drug effects; Peroxidase/drug effects; Rats; Rats, Sprague-Dawley

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chemical Warfare Agents / Metalloporphyrins / Mustard Gas / Antioxidants Limits: Animals Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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