Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.

Zheng, Shuqiu; Clabough, Erin B D; Sarkar, Sovan; Futter, Marie; Rubinsztein, David C; Zeitlin, Scott O

Zheng, Shuqiu; Clabough, Erin B D; Sarkar, Sovan; Futter, Marie; Rubinsztein, David C; Zeitlin, Scott O.

Affiliation

Zheng S; Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America.

PLoS Genet ; 6(2): e1000838, 2010 Feb 05.

Article in En | MEDLINE | ID: mdl-20140187

Subject(s)

Autophagy; Longevity; Nerve Tissue Proteins/genetics; Neurons/pathology; Nuclear Proteins/genetics; Peptides/genetics; Sequence Deletion/genetics; Animals; Autophagy-Related Protein 5; Behavior, Animal; Cell Line; Disease Models, Animal; Humans; Huntingtin Protein; Huntington Disease/metabolism; Huntington Disease/pathology; Intracellular Signaling Peptides and Proteins/metabolism; Lipofuscin/metabolism; Mice; Microtubule-Associated Proteins/metabolism; Motor Activity; Neostriatum/metabolism; Neostriatum/pathology; Nerve Tissue Proteins/chemistry; Nerve Tissue Proteins/metabolism; Neuropil/metabolism; Neuropil/pathology; Nuclear Proteins/chemistry; Nuclear Proteins/metabolism; Phagosomes/metabolism; Protein Serine-Threonine Kinases/metabolism; Protein Structure, Quaternary; Signal Transduction; TOR Serine-Threonine Kinases

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Autophagy / Nuclear Proteins / Sequence Deletion / Longevity / Nerve Tissue Proteins / Neurons Limits: Animals / Humans Language: En Journal: PLoS Genet Journal subject: GENETICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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