Tumor-induced osteomalacia originating from the temporal bone: a case report.
Head Neck
; 33(7): 1072-5, 2011 Jul.
Article
in En
| MEDLINE
| ID: mdl-20146335
ABSTRACT
BACKGROUND:
Tumor-induced osteomalacia (TIO) is a rare clinical entity in which secondary osteomalacia is induced by tumor-related products. Fibroblast growth factor 23 (FGF-23) mRNA is overexpressed in the tumor tissue, leading to impaired reabsorption of phosphorus in the renal tubules and hypophosphatemia. Curative treatment is considered to be total resection of the tumor. METHODS ANDRESULTS:
A 53-year-old woman had experienced systemic bone pain and muscle weakness for several years. She had refractory hypophosphatemia and marked elevation of serum FGF-23 level. Whole body imaging eventually revealed a hypervascular mass in the right temporal bone, leading to a diagnosis of TIO. She underwent skull-base surgery after embolization of the tumor. After the en bloc resection, FGF-23 became undetectable, phosphate reabsorption normalized, and all symptoms resolved.CONCLUSIONS:
We discuss the clinical features and treatment options for this rare disease.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteomalacia
/
Skull Neoplasms
/
Temporal Bone
/
Fibroblast Growth Factors
/
Neoplasms, Connective Tissue
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Head Neck
Journal subject:
NEOPLASIAS
Year:
2011
Document type:
Article
Affiliation country:
Japan