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MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans.
Atack, J R; Wafford, K A; Street, L J; Dawson, G R; Tye, S; Van Laere, K; Bormans, G; Sanabria-Bohórquez, S M; De Lepeleire, I; de Hoon, J N; Van Hecken, A; Burns, H D; McKernan, R M; Murphy, M G; Hargreaves, R J.
Affiliation
  • Atack JR; Neuroscience Research Centre, Merck Sharp & Dohme Research Laboratories, Harlow, UK. JAtack1@its.jnj.com
J Psychopharmacol ; 25(3): 314-28, 2011 Mar.
Article in En | MEDLINE | ID: mdl-20147571
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anxiety / Anti-Anxiety Agents / GABA-A Receptor Agonists / Heterocyclic Compounds, 4 or More Rings / Hydrocarbons, Fluorinated Type of study: Clinical_trials / Etiology_studies / Prognostic_studies Language: En Journal: J Psychopharmacol Journal subject: PSICOFARMACOLOGIA Year: 2011 Document type: Article Affiliation country: United kingdom Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anxiety / Anti-Anxiety Agents / GABA-A Receptor Agonists / Heterocyclic Compounds, 4 or More Rings / Hydrocarbons, Fluorinated Type of study: Clinical_trials / Etiology_studies / Prognostic_studies Language: En Journal: J Psychopharmacol Journal subject: PSICOFARMACOLOGIA Year: 2011 Document type: Article Affiliation country: United kingdom Country of publication: United States