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Substituted fused bicyclic pyrrolizinones as potent, orally bioavailable hNK1 antagonists.
Morriello, Gregori J; Mills, Sander G; Johnson, Tricia; Reibarkh, Mikhail; Chicchi, Gary; DeMartino, Julie; Kurtz, Marc; Davies, P; Tsao, K L C; Zheng, Song; Tong, Xinchun; Carlson, Emma; Townson, Karen; Tattersall, F D; Wheeldon, Alan; Boyce, Susan; Collinson, Neil; Rupniak, Nadia; Moore, Stephen; DeVita, Robert J.
Affiliation
  • Morriello GJ; Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. greg_morriello@merck.com
Bioorg Med Chem Lett ; 20(6): 2007-12, 2010 Mar 15.
Article in En | MEDLINE | ID: mdl-20153964
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Bridged Bicyclo Compounds / Neurokinin-1 Receptor Antagonists Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Bridged Bicyclo Compounds / Neurokinin-1 Receptor Antagonists Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United kingdom