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The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.
Blouin, Marc; Han, Yongxin; Burch, Jason; Farand, Julie; Mellon, Christophe; Gaudreault, Mireille; Wrona, Mark; Lévesque, Jean-François; Denis, Danielle; Mathieu, Marie-Claude; Stocco, Rino; Vigneault, Erika; Therien, Alex; Clark, Patsy; Rowland, Steve; Xu, Daigen; O'Neill, Gary; Ducharme, Yves; Friesen, Rick.
Affiliation
  • Blouin M; Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada Ltd., 16771 Trans-Canada Highway, Kirkland, QC, Canada. marc_blouin@merck.com
J Med Chem ; 53(5): 2227-38, 2010 Mar 11.
Article in En | MEDLINE | ID: mdl-20163116
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostaglandin Antagonists / Thiophenes / Benzoates / Receptors, Prostaglandin E / Cyclopropanes / Analgesics Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Document type: Article Affiliation country: Canada
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostaglandin Antagonists / Thiophenes / Benzoates / Receptors, Prostaglandin E / Cyclopropanes / Analgesics Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Document type: Article Affiliation country: Canada