Extending hepatocyte functionality for drug-testing applications using high-viscosity alginate-encapsulated three-dimensional cultures in bioreactors.

Miranda, Joana P; Rodrigues, Armanda; Tostões, Rui M; Leite, Sofia; Zimmerman, Heiko; Carrondo, Manuel J T; Alves, Paula M

Miranda, Joana P; Rodrigues, Armanda; Tostões, Rui M; Leite, Sofia; Zimmerman, Heiko; Carrondo, Manuel J T; Alves, Paula M.

Affiliation

Miranda JP; Animal Cell Technology Laboratory, ITQB-UNL/IBET, Oeiras, Portugal.

Tissue Eng Part C Methods ; 16(6): 1223-32, 2010 Dec.

Article in En | MEDLINE | ID: mdl-20184401

Subject(s)

Alginates/chemistry; Bioreactors; Drug Evaluation, Preclinical/methods; Hepatocytes/cytology; Hepatocytes/physiology; Animals; Biotransformation/drug effects; Biotransformation/physiology; Cell Culture Techniques/instrumentation; Cell Culture Techniques/methods; Cells, Cultured; Cytochrome P-450 Enzyme System/analysis; Cytochrome P-450 Enzyme System/metabolism; Glucuronic Acid/chemistry; Hepatocytes/enzymology; Hexuronic Acids/chemistry; Hydrogel, Polyethylene Glycol Dimethacrylate/chemistry; Hydrogel, Polyethylene Glycol Dimethacrylate/pharmacology; Male; Rats; Rats, Wistar; Tissue Scaffolds/chemistry; Viscosity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bioreactors / Hepatocytes / Drug Evaluation, Preclinical / Alginates Type of study: Evaluation_studies Limits: Animals Language: En Journal: Tissue Eng Part C Methods Journal subject: BIOTECNOLOGIA / HISTOLOGIA Year: 2010 Document type: Article Affiliation country: Portugal Country of publication: United States

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