Novel mucosal vaccines generated by genetic conjugation of heterologous proteins to pneumolysin (PLY) from Streptococcus pneumoniae.

Douce, Gill; Ross, Kirsty; Cowan, Graeme; Ma, Jiangtao; Mitchell, Tim J

Douce, Gill; Ross, Kirsty; Cowan, Graeme; Ma, Jiangtao; Mitchell, Tim J.

Affiliation

Douce G; Division of Infection and Immunity, Faculty of Biomedical and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK.

Vaccine ; 28(18): 3231-7, 2010 Apr 19.

Article in En | MEDLINE | ID: mdl-20188176

Subject(s)

Adjuvants, Immunologic/pharmacology; Immunity, Mucosal; Proteins/immunology; Streptolysins/pharmacology; Vaccines/immunology; Adhesins, Bacterial/genetics; Adhesins, Bacterial/immunology; Adjuvants, Immunologic/genetics; Adjuvants, Immunologic/toxicity; Animals; Antibodies/blood; Bacterial Proteins/genetics; Bacterial Proteins/pharmacology; Bacterial Proteins/toxicity; Female; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/immunology; Humans; Immunoglobulin A/analysis; Immunoglobulin A/blood; Immunoglobulin G/blood; Lipoproteins/genetics; Lipoproteins/immunology; Mice; Mice, Inbred BALB C; Proteins/genetics; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/immunology; Sequence Deletion; Streptolysins/genetics; Streptolysins/toxicity; Vaccines/genetics; Vaccines, Synthetic/genetics; Vaccines, Synthetic/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptolysins / Vaccines / Proteins / Adjuvants, Immunologic / Immunity, Mucosal Limits: Animals / Female / Humans Language: En Journal: Vaccine Year: 2010 Document type: Article Affiliation country: United kingdom

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