[Determination of cefixime blood plasma levels by HPLC].
Antibiot Khimioter
; 54(7-8): 37-40, 2009.
Article
in Ru
| MEDLINE
| ID: mdl-20201402
ABSTRACT
For comparative study of the pharmacokinetics of Cemidexor (capsules of 100 mg) and Suprax (capsules of 400 mg), a method of HPLC with quantitative determination of cefixime (the active substance in the drugs) in the blood plasma of patients with UV detection was developed. The data teproducibility with an account of the admissibility criterion was observed within the interval of all the concentrations (0.06-10 mcg/ml). The accuracy and correctness of the method also corresponded to the admissibility criteria. The lower limit of the quantitative determimation of the cefexime blood plasma levels was 0.06 mcg/ml. The pharmacokinetics was studied with the open crossed randomized method. The results were used for calculation of the pharmacokinetic parameters required for estimation of the bioequivalence of the drugs. The statistical analysis of the pharmacokinetic parameters showed that Cemidoxor and Suprax were bioequivalent.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromatography, High Pressure Liquid
/
Cefixime
/
Anti-Bacterial Agents
Type of study:
Clinical_trials
/
Diagnostic_studies
Limits:
Humans
Language:
Ru
Journal:
Antibiot Khimioter
Journal subject:
TERAPIA POR MEDICAMENTOS
Year:
2009
Document type:
Article