Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9.

Finlay, Trisha M; Jayanth, Preethi; Amith, Schammim Ray; Gilmour, Alanna; Guzzo, Christina; Gee, Katrina; Beyaert, Rudi; Szewczuk, Myron R

Finlay, Trisha M; Jayanth, Preethi; Amith, Schammim Ray; Gilmour, Alanna; Guzzo, Christina; Gee, Katrina; Beyaert, Rudi; Szewczuk, Myron R.

Affiliation

Finlay TM; Department of Microbiology & Immunology, Queen's University, Kingston, ON, K7L3N6, Canada. tmfinlay@ucalgary.ca

Glycoconj J ; 27(3): 329-48, 2010 Apr.

Article in En | MEDLINE | ID: mdl-20213245

Subject(s)

Benzoquinones/pharmacology; Fibroblasts/enzymology; Macrophages/enzymology; Matrix Metalloproteinase 9/metabolism; Mucolipidoses/enzymology; Neuraminidase/metabolism; Nigella sativa/chemistry; Receptors, G-Protein-Coupled/metabolism; Animals; Benzoquinones/chemistry; Blotting, Western; Cell Line; Cell Survival/drug effects; Cells, Cultured; Enzyme Activation/drug effects; Flow Cytometry; Humans; Immunohistochemistry; Immunoprecipitation; Mice; Mice, Knockout; Polymerase Chain Reaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nigella sativa / Benzoquinones / Matrix Metalloproteinase 9 / Receptors, G-Protein-Coupled / Fibroblasts / Macrophages / Mucolipidoses / Neuraminidase Limits: Animals / Humans Language: En Journal: Glycoconj J Journal subject: BIOQUIMICA / METABOLISMO Year: 2010 Document type: Article Affiliation country: Canada Country of publication: United States

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