SAMe prevents the induction of the immunoproteasome and preserves the 26S proteasome in the DDC-induced MDB mouse model.

Bardag-Gorce, Fawzia; Oliva, Joan; Li, Jun; French, Barbara A; French, Samuel W

Bardag-Gorce, Fawzia; Oliva, Joan; Li, Jun; French, Barbara A; French, Samuel W.

Affiliation

Bardag-Gorce F; Department of Pathology, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90509, USA. fgorce@labiomed.org

Exp Mol Pathol ; 88(3): 353-62, 2010 Jun.

Article in En | MEDLINE | ID: mdl-20223233

Subject(s)

Liver Diseases, Alcoholic/prevention & control; Proteasome Endopeptidase Complex/metabolism; S-Adenosylmethionine/pharmacology; Animals; Base Sequence; Cysteine Endopeptidases/genetics; Cysteine Endopeptidases/metabolism; DNA Primers/genetics; Dihydropyridines/toxicity; Disease Models, Animal; Gene Expression/drug effects; Inclusion Bodies/drug effects; Inclusion Bodies/metabolism; Inclusion Bodies/pathology; Keratins/metabolism; Liver/drug effects; Liver/metabolism; Liver/pathology; Liver Diseases, Alcoholic/etiology; Liver Diseases, Alcoholic/metabolism; Liver Diseases, Alcoholic/pathology; Male; Mice; Mice, Inbred C3H; Multienzyme Complexes/genetics; Multienzyme Complexes/metabolism; Proteasome Endopeptidase Complex/chemistry; Proteasome Endopeptidase Complex/drug effects; Ubiquitin/metabolism; Ubiquitins/genetics; Ubiquitins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: S-Adenosylmethionine / Proteasome Endopeptidase Complex / Liver Diseases, Alcoholic Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Exp Mol Pathol Year: 2010 Document type: Article Affiliation country: United States Country of publication: Netherlands

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