The antiendotoxin agent taurolidine potentially reduces ischemia/reperfusion injury through its metabolite taurine.

Doddakula, Kishore K; Neary, Peter M; Wang, Jiang H; Sookhai, Shastri; O'Donnell, Aongus; Aherne, Tom; Bouchier-Hayes, David J; Redmond, Henry P

Doddakula, Kishore K; Neary, Peter M; Wang, Jiang H; Sookhai, Shastri; O'Donnell, Aongus; Aherne, Tom; Bouchier-Hayes, David J; Redmond, Henry P.

Affiliation

Doddakula KK; Department of Cardiac Surgery, University College Cork, Cork University Hospital, Cork, Ireland.

Surgery ; 148(3): 567-72, 2010 Sep.

Article in En | MEDLINE | ID: mdl-20223497

Subject(s)

Coronary Artery Bypass/methods; Endotoxins/adverse effects; Reperfusion Injury/prevention & control; Taurine/analogs & derivatives; Taurine/metabolism; Aged; Antioxidants/therapeutic use; Cardiopulmonary Bypass/methods; Constriction; Coronary Artery Bypass/adverse effects; Endotoxins/therapeutic use; Female; Heart Arrest, Induced/methods; Humans; Interleukin-10/blood; Interleukin-6/blood; Length of Stay; Male; Middle Aged; Phagocytosis/physiology; Placebos; Reperfusion Injury/etiology; Respiratory Burst/physiology; Taurine/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Taurine / Reperfusion Injury / Coronary Artery Bypass / Endotoxins Type of study: Clinical_trials / Etiology_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Surgery Year: 2010 Document type: Article Affiliation country: Ireland

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