In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.

Salomão, K; de Souza, E M; Carvalho, S A; da Silva, E F; Fraga, C A M; Barbosa, H S; de Castro, S L

Salomão, K; de Souza, E M; Carvalho, S A; da Silva, E F; Fraga, C A M; Barbosa, H S; de Castro, S L.

Affiliation

Salomão K; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brazil.

Antimicrob Agents Chemother ; 54(5): 2023-31, 2010 May.

Article in En | MEDLINE | ID: mdl-20231395

Subject(s)

Chagas Disease/drug therapy; Hydrazones/pharmacology; Thiadiazoles/pharmacology; Trypanosoma cruzi/drug effects; Alanine Transaminase/blood; Animals; Antiprotozoal Agents/chemistry; Antiprotozoal Agents/pharmacology; Aspartate Aminotransferases/blood; Body Weight; Cells, Cultured; Chagas Disease/mortality; Chagas Disease/parasitology; Hydrazones/chemistry; In Vitro Techniques; Inhibitory Concentration 50; Macrophages, Peritoneal/cytology; Macrophages, Peritoneal/parasitology; Male; Mice; Microscopy, Electron, Scanning; Myocytes, Cardiac/cytology; Myocytes, Cardiac/parasitology; Parasitemia/drug therapy; Parasitemia/mortality; Parasitemia/parasitology; Thiadiazoles/chemistry; Trypanosoma cruzi/growth & development; Trypanosoma cruzi/ultrastructure; Urea/blood

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiadiazoles / Trypanosoma cruzi / Chagas Disease / Hydrazones Limits: Animals Language: En Journal: Antimicrob Agents Chemother Year: 2010 Document type: Article Affiliation country: Brazil

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