Determination of N-acetylcysteine in human plasma by gas chromatography-mass spectrometry.
J Chromatogr
; 562(1-2): 639-45, 1991 Jan 02.
Article
in En
| MEDLINE
| ID: mdl-2026726
ABSTRACT
An automatic mass spectrometric method for the quantitation of N-acetylcysteine (NAC) in human plasma has been developed. NAC was extracted from plasma with ethyl acetate and derivatized in two steps with 2-propanol and pentafluoropropionic anhydride. The volatile derivative obtained was ideal for gas chromatographic-mass spectrometric analysis. Data obtained by analysing the plasma of healthy volunteers to whom 600 mg of NAC had been orally given are reported.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acetylcysteine
Limits:
Humans
Language:
En
Journal:
J Chromatogr
Year:
1991
Document type:
Article
Affiliation country:
Italy