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Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.
Skerlj, Renato T; Bridger, Gary J; Kaller, Al; McEachern, Ernest J; Crawford, Jason B; Zhou, Yuanxi; Atsma, Bem; Langille, Jonathon; Nan, Susan; Veale, Duane; Wilson, Trevor; Harwig, Curtis; Hatse, Sigrid; Princen, Katrien; De Clercq, Erik; Schols, Dominique.
Affiliation
  • Skerlj RT; Genzyme Corp., 153 Second Avenue, Waltham, Massachusetts 02451, USA. renato.skerlj@genzyme.com
J Med Chem ; 53(8): 3376-88, 2010 Apr 22.
Article in En | MEDLINE | ID: mdl-20297846
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV-1 / Anti-HIV Agents / Receptors, CXCR4 / Heterocyclic Compounds, 1-Ring Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV-1 / Anti-HIV Agents / Receptors, CXCR4 / Heterocyclic Compounds, 1-Ring Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States