24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] controls growth plate development by inhibiting apoptosis in the reserve zone and stimulating response to 1alpha,25(OH)2D3 in hypertrophic cells.

Boyan, B D; Hurst-Kennedy, J; Denison, T A; Schwartz, Z

Boyan, B D; Hurst-Kennedy, J; Denison, T A; Schwartz, Z.

Affiliation

Boyan BD; Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, ATlanta, GA 30332-0363, USA. barbara.boyan@bme.gatech.edu

J Steroid Biochem Mol Biol ; 121(1-2): 212-6, 2010 Jul.

Article in En | MEDLINE | ID: mdl-20307662

Subject(s)

Apoptosis; Calcitriol/metabolism; Growth Plate/metabolism; 24,25-Dihydroxyvitamin D 3/metabolism; Animals; Caspase 3/metabolism; Cell Proliferation; Chondrocytes/cytology; Enzyme Activation; Growth Plate/drug effects; Hypertrophy; Lysophospholipids/metabolism; Male; Phospholipases A2/metabolism; Rats; Rats, Sprague-Dawley; Tumor Suppressor Protein p53/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcitriol / Apoptosis / Growth Plate Limits: Animals Language: En Journal: J Steroid Biochem Mol Biol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United kingdom

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